Seminole County Jane Doe is a female who, along with her husband and children, died of yellow fever in 1887 in the failed colony of St. Joseph, Florida. They were a Dutch or German Catholic immigrant family.

They are now buried in a small family plot that was paved under Interstate 4 between the south end of the bridge crossing the St. Johns River and the railroad overpass. The area they are buried in is also referred to as the "I-4 Dead Zone" or "Field of the Dead" because of the number of deadly car accidents and strange occurrences that have happened.

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